Relation of CD81-CD19 in autoimmune disease

CD81 and CD19: What They Have to Do with Autoimmune Diseases

Okay, so let’s break this down! You know how our immune system is supposed to protect us from getting sick? Well, there are certain proteins on our immune cells, like CD81 and CD19, that play a big role in helping our immune system do its job. But when these proteins mess up, they can actually cause some serious problems. Let’s dive in!

What are CD81 and CD19?

• CD81 and CD19 are proteins found on immune cells, especially B cells. These are like little soldiers that help fight off infections.

• CD81 helps immune cells talk to each other so they can work together better.

• CD19 helps B cells become active and create antibodies that fight germs.

  
  

How Do They Work Together?

• CD81 and CD19 team up on B cells to help them respond to infections. They make B cells stronger and better at making antibodies that protect you from getting sick.

  
  

What Happens in Autoimmune Diseases?

So here’s the thing: In autoimmune diseases (like lupus or rheumatoid arthritis), the immune system gets confused and starts attacking the body’s own tissues instead of just germs. How does this happen?

• Overactive B cells: When CD81 and CD19 don’t work the way they’re supposed to, B cells go crazy. Instead of just fighting infections, they start making auto antibodies that attack healthy body cells.

• Losing control: Normally, B cells know not to attack your own body. But when CD81 and CD19 don’t work right, B cells can lose that ability and start causing trouble.

  
  

Why Should We Care?

• When CD81 and CD19 aren’t doing their job, it can lead to diseases where the immune system attacks itself, which is super not good.

• Scientists are studying these proteins because fixing them might be the key to stopping autoimmune diseases.

  
  

Could We Treat Autoimmune Diseases This Way?

• Researchers are looking into targeting CD81 and CD19 to help control the overactive B cells in autoimmune diseases.

• If we can fix these proteins, we might be able to stop the immune system from attacking the body and causing harm.

  
  

TL;DR

• CD81 and CD19 are proteins that help B cells protect us from infections.

• When they stop working properly, B cells can start attacking the body, leading to autoimmune diseases.

• Scientists are studying these proteins to help treat autoimmune diseases and keep the immune system in check.

  
  

So, next time you hear about CD81 or CD19, you'll know they're super important for keeping our immune system balanced. When they mess up, though, things can get a little out of hand! So can CD19 or CD81 CAR T cells be used for the treatment of refractory autoimmune diseases? Lets dive into it in next few blogs and experiment it!

Stay tuned.